Following is a fascinating guest post about "The Ether Dome" and the world of pre-anesthesia surgery by Sarah Alger , director of the Paul S. Russell, MD Museum of Medical History and Innovation at Massachusetts General Hospital . You can follow her on Twitter at @slodoena . “The horror of great darkness, and the sense of desertion by God and man, bordering close on despair, which swept through my mind and overwhelmed my heart, I can never forget, however gladly I would do so ... I still recall with unwelcome vividness the spreading out of the instruments, the twisting of the tourniquet, the first incision, the fingering of the sawed bone, the sponge pressed on the flap, the tying of the blood-vessels, the stitching of the skin, the bloody dismembered limb lying on the floor.” Such was surgery before anesthesia, as described by George Wilson, who underwent an ankle amputation in 1843. When Massachusetts General Hospital in Boston was designed in the early 1800s...